Miglitol
A to Z Drug Facts
Miglitol |
(mig-LIH-tall) |
Glyset |
Class: Antidiabetic/Alpha-glucosidase inhibitor |
Action Inhibits intestinal enzymes that digest carbohydrates, thereby reducing carbohydrate digestion after meals, which lowers postprandial glucose elevation in diabetics.
Indications Patients with NIDDM who have failed dietary therapy. May be used alone or in combination with sulfonylureas.
Contraindications Diabetic ketoacidosis; inflammatory bowel disease; colonic ulceration; ntestinal disorders of digestion or absorption; partial or predisposition to intestinal obstruction; conditions that may deteriorate as a result of increased intestinal gas production.
ADULTS: PO 25 mg tid at the start of each meal. After 48 weeks can increase to 50 mg/dose for 3 months. If glycosylated hemoglobin level not acceptable after 3 months can increase at 100 mg tid (maximum dose).
Intestinal absorbents (eg, charcoal), digestive enzymes: May lower efficacy of miglitol. Drugs that produce hyperglycemia (eg, corticosteroids, diuretics, thyroid preparations): May lead to loss of glucose control. Ranitidine: Reduced ranitidine bioavailability. Propranolol: Reduced propranolol bioavailability.
Lab Test Interferences Transient decreases in serum iron that are not associated with hemoglobin reduction or other changes in hematologic indices.
DERM: Rash. GI: Abdominal pain; diarrhea; flatulence.
Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Hypoglycemia: Miglitol does not produce hypoglycemia; however, hypoglycemia may develop if used together with sulfonylureas. Use glucose (dextrose) and not cane sugar table sugar) or fruits/fruit juices to treat hypoglycemia. Loss of blood glucose control: Certain medical conditions (eg, surgery, fever, infection, or trauma) nd drugs (eg, diuretics, corticosteroids, oral contraceptives) affect glucose control. In these situations, it may be necessary to adjust the dose of miglitol and other antidiabetic drugs. Renal impairment: Miglitol not recommended if serum creatinine > 2.0 mg/dl.
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Books@Ovid
Copyright © 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts